Supporting Roles of Platelet Thrombospondin-1 and CD36 in Thrombus Formation on Collagen

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Supporting roles of platelet thrombospondin-1 and CD36 in thrombus formation on collagen.

OBJECTIVE Platelets abundantly express the membrane receptor CD36 and store its ligand thrombospondin-1 (TSP1) in the α-granules. We investigated whether released TSP1 can support platelet adhesion and thrombus formation via interaction with CD36. APPROACH AND RESULTS Mouse platelets deficient in CD36 showed reduced adhesion to TSP1 and subsequent phosphatidylserine expression. Deficiency in ...

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Fibronectin is required for platelet adhesion and for thrombus formation on subendothelium and collagen surfaces.

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ژورنال

عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology

سال: 2014

ISSN: 1079-5642,1524-4636

DOI: 10.1161/atvbaha.113.302917